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Additional file 3 of Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library

Figshare2020-11-23 更新2026-04-28 收录

功能基因组筛选

sgRNA文库设计

数据链接：

https://figshare.com/articles/dataset/Additional_file_3_of_Genome-scale_CRISPR_screening_at_high_sensitivity_with_an_empirically_designed_sgRNA_library/13278615 数据链接链接失效反馈

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资源简介：

Additional file 3: File S1. sgRNA sequences of the HD CRISPR Library A.

应用场景：

创建时间：

2020-11-23

癌症分子机制

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Background: LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mous

NIAID Data Ecosystem20

Genome_scale_identification_of_cellular_pathways_required_for_cell_surface_recognition. Genome_scale_identification_of_cellular_pathways_required_for_cell_surface_recognition

细胞表面受体识别

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Interactions mediated by cell surface receptors initiate important instructive signaling cues but can be difficult to detect in biochemical assays because they are often highly transient and membrane-

NIAID Data Ecosystem20

sgRNA cassette sequencing from H226 cells with doxycycline-inducible p63-targeting shRNA construct, treated with doxycycline for 14 days

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p63基因功能研究

Genome-wide CRISPR/Cas9-based screen to identify anti-proliferative genes during ?Np63a depletion Overall design: H226 cells transduced with the GeCKOv2 A and B libraries were treated to induce p63 kn

NIAID Data Ecosystem00

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma [shRNA]. UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma [shRNA]

KRAS突变机制

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Using pooled shRNA libraries we performed a focused screen of 115 genes in 3D ex vivo cultures of primary murine lung tumor cells and 2D cultures of murine LKR10 cells. These screens identify Uhrf1 as

NIAID Data Ecosystem20

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

冠状病毒-宿主互作机制

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The ongoing SARS-CoV-2 pandemic has devastated the global economy and claimed more than one million lives, presenting an urgent global health crisis. To identify host factors required for infection by

NIAID Data Ecosystem10

Additional file 3 of Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library

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