Two Yb(III) coordination polymers: treatment effect with seventy-flavor pearl pills on cerebral ischemia by reducing the content of monoamine neurotransmitters

In the current study, we have successfully prepared two new Yb(III)-based coordination polymers with the chemical formulae of {[Yb(cptz)2(H2O)4]·NO3}n (1, Hcptz = (4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole) and {[Yb(Hpbdz)(H2O)2]·H2O}n (2, H4pbdz = 1,1′-(propane-1,3-diyl)bis(1H-imidazole-4,5-dicarboxylic acid) under hydrothermal conditions by using two N-heterocyclic multidentate N, O-donor bridging ligands. In the biological functional study, the promotion activity of compounds 1 and 2 on the treatment effect of the seventy-flavor pearl pills on the cerebral ischemic events was evaluated in vivo. Firstly, the content of dopamine and 5-serotonin in the brain after compounds 1 and 2 treatment was assessed by the ELISA detection kit. Then, the inhibitory effect of compounds 1 and 2 on the inflammatory level in the brain was determined with the ROS detection kit.