Functional properties of clobazam, N-desmethylclobazam, and clonazepam at the human α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, α6β2δ and α6β2GABAARs expressed in Xenopus oocytes.

a The concentration-response curves for N-desmethylclobazam at the α6β2δ and α6β2GABAARs were not saturated at the maximal concentration used (1 mM). Thus, for this receptors the EC50 and pEC50 values for N-desmethylclobazam are estimated from the data, and the currents evoked by 1 mM N-desmethylclobazam (in % of the GABA EC20 response) is given instead of Imax.b The properties for N-desmethylclobazam at α5β2γ2S and for clonazepam at α3β2γ2S are based on two independent experiments (n = 2), and thus the mean EC50 and Imax values for the modulators are given with specific EC50 and Imax values determined in the two experiments in parantheses.Functional properties of clobazam, N-desmethylclobazam, and clonazepam at the human α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, α6β2δ and α6β2GABAARs expressed in Xenopus oocytes.