Top-Ten Sensitive Deletion Strains in Genome-Wide Profiles of FDA-Approved Serotonergic and Dopaminergic Drugs*.

*Essential genes are in bold, and gene functions that occur frequently in the table are indicated with letters. V = vesicle transport, protein transport and localization, D = DNA repair, P = protein folding, actin and tubulin assembly, R = RNA processing, transcription, translation, ribosomal function, A = amino acid biosynthesis and metabolism. For bromocriptine, we scored only one significantly sensitive strain, trp3��, which is involved in aromatic amino acid biosynthesis (z>3, r>2). Strains were sorted according to their fitness ratio, using average ratios for replicated drugs and removing dubious ORFs.