Screening of anti-Acinetobacter baumannii phytochemicals, based on the potential inhibitory effect on OmpA and OmpW functions

Considering the adverse effect of antimicrobial resistance (AMR) crisis on human life, there is an immediate need for finding new alternative drugs for treatment of emerging infectious diseases. Therapeutic options, including last-line or combined antibiotic therapies for Acinetobacter baumannii, as a multi-drug resistant (MDR) human pathogen responsible for severe nosocomial and several other infections, are apparently ineffective. The outer membrane protein A (OmpA) and outer membrane protein W (OmpW) are two porins known for their different cellular functions. Identification of natural compounds with potentials to block these putative porins can possibly attenuate the growth of the bacteria and control the relating diseases. The current work aimed to screen a library of 384 phytochemicals according to their potentials to be used as a drug, and potentials to inhibit the function of OmpA and OmpW in A. baumannii. Although the anti-virulence activities of these biomolecules are reported...