Combined Immunomodulation and Antiviral Therapy for Respiratory Syncytial Virus

Bovine respiratory syncytial virus (BRSV) plays a major role in etiology of the bovine respiratory disease complex. In this work calves also served as a model for understanding human respiratory syncytial virus infection. The goal of this study was to evaluate in vivo the effect of ibuprofen and fusion protein inhibitor (FPI). Calves were divided to 6 treatment groups: 1) ibuprofen day 3-10, 2) ibuprofen day 5 -10, 3) placebo, 4) FPI day 5-10, 5) FPI and ibuprofen day 5-10, 6) FPI and ibuprofen day 3-10 and were infected with BRSV (day 0). At necropsy (day10) lung tissue with lesions and non lesion, was collected, as well as bronchial and mediastinal lymph nodes. Lung lavage was collected before infection and on day 10. Peripheral blood was collected before infection and on day 4, 6, 8, 10 after infection.