Heterogeneous immune cell types modulate the neonatal lung response to hyperoxia

During the first days of life, the lung surface area increases explosively to enable efficient oxygen exchange. Perturbations to the neonatal environment can profoundly affect the abundance, gene expression, organisation, and function of lung cells. Here, we build upon previous experiments and exposed newborn mice to 80% oxygen for the first seven days of life, followed by single cell transcriptomics of immune cells. Overall design: scRNA-Seq on FACS sorted cells