In Vitro Activities of Linezolid against Multiple Nocardia Species

Linezolid was tested by broth microdilution against 140 clinical Nocardia isolates belonging to seven species. The MIC at which 50% of the strains are inhibited (MIC(50)) and MIC(90) for all species other than Nocardia farcinica were 2 and 4 μg/ml. Linezolid is the first antimicrobial agent demonstrated to be active against all Nocardia species.