Dissecting transcriptional heterogeneity in sinonasal adenocarcinoma by single-cell RNA sequencing

We have employed a single-cell RNA sequencing (scRNA-seq) approach using 10x Genomics scRNAseq to profile from 3 sinonasal adenocarcinoma (SNAC) tumors. It constructed a comprehensive single-cell transcriptional atlas, revealing profound cellular and molecular heterogeneity within the SNAC microenvironment. Overall design: Three patients with recurrent sinonasal adenocarcinoma, each collected a primary tumor tissue sample through surgical resection or endoscopic biopsy, analyzed using scRNA-seq.