Regulation of human oocyte maturation through non-CG methylation

Oocyte maturation is a coordinated process that is tightly linked to reproductive potential. A better understanding of genome regulation during human oocyte maturation will not only answer an important question in biology, but also facilitate the development of in vitro maturation technology as a fertility treatment. We generated single-cell transcriptome and methylome data from human oocytes at different maturation stages to investigate how the genome is regulated during oocyte maturation, focusing on the potential regulatory role of non-CG methylation.