Drosophila WDFY3/Bchs overexpression impairs neural function

Tab S1. Differentially expressed genes of glial Bchs overexpression flies. Gene expression levels from glial Bchs overexpression flies (repo>bchs) was compared to the respective controls (repo-Gal4/+ and UAS-bchs/+). Genes were considered to be significantly differentially expressed if adjusted p-value < 0.05. baseMean: mean of normalized counts of all samples; log2FoldChange: log2 difference of the gene expression level in Bchs overexpression flies compared to the control group; lfcSE: standard error of log2 fold change; stat: Wald statistic; pvalue: Wald test p-value; padj: p-value adjusted by Benjamini-Hochberg method.

Tab S2. Differentially expressed genes of neuronal Bchs overexpression flies. Gene expression levels from neuronal Bchs overexpression flies (nSyb>bchs) was compared to the respective controls (nSyb-Gal4/+ and UAS-bchs/+). Genes were considered to be significantly differentially expressed if adjusted p-value < 0.05. baseMean: mean of normalized counts of all samples; log2FoldChange: log2 difference of the gene expression level in Bchs overexpression flies compared to the control group; lfcSE: standard error of log2 fold change; stat: Wald statistic; pvalue: Wald test p-value; padj: p-value adjusted by Benjamini-Hochberg method.

Tab S3. Genes differentially expressed in glial and neuronal Bchs overexpression flies. Genes are listed which were differentially expressed in both, glial and neuronal Bchs overexpression flies. Glial/neuronal direction: states whether the gene expression was down- or up-regulated in glial and neuronal Bchs overexpression flies, respectively; concordance: states whether the gene expression was dysregulated in the same direction in glial and neuronal Bchs overexpression flies.

Tab S4. GO enrichment analysis from differentially expressed genes of glial Bchs overexpression flies. Gene differentially expressed in glial Bchs overexpression flies (repo>bchs) were subjected to GO enrichment analysis. GO modules were considered to be significantly enriched with a p-value after family wise error rate multiple correction (padj) < 0.05.

Tab S5. GO enrichment analysis from differentially expressed genes of neuronal Bchs overexpression flies. Gene differentially expressed in neuronal Bchs overexpression flies (repo>bchs) were subjected to GO enrichment analysis. GO modules were considered to be significantly enriched with a p-value after family wise error rate multiple correction (padj) < 0.05.

Tab S6. GO enrichment analysis from genes differentially expressed in glial and neuronal Bchs overexpression flies. Gene differentially expressed in both, glial and neuronal Bchs overexpression flies (repo>bchs and nSyb>bchs), were subjected to GO enrichment analysis. GO modules were considered to be significantly enriched with a p-value after family wise error rate multiple correction (padj) < 0.05.