A shared MHC immunogenetic signal connects aging, rheumatoid arthritis, and herpes zoster through chronic high inflammatory burden–compensatory immune tolerance dysregulation

This repository contains the analysis scripts, supplementary interactive files, and full summary results supporting the manuscript: "A shared MHC immunogenetic signal connects aging, rheumatoid arthritis, and herpes zoster through chronic high inflammatory burden–compensatory immune tolerance dysregulation".

By integrating large-scale genome-wide association studies (GWAS) of a multivariate aging latent factor (mvAge), rheumatoid arthritis (RA), and herpes zoster (HZ) with multi-omics quantitative trait loci (including bulk eQTLs, single-cell eQTLs, and plasma pQTLs), this framework dissects the shared genetic and molecular architecture linking aging, autoimmunity, and viral reactivation.

The compressed file is structured into three main directories. The organization of the code and results meticulously aligns with the Methods section of the manuscript, providing data support for the proposed life-course "chronic high inflammatory burden–compensatory immune tolerance dysregulation" model.