Synaptome data from sleep wake cycle and sleep deprivation
收藏DataCite Commons2024-07-25 更新2025-04-17 收录
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https://datashare.ed.ac.uk/handle/10283/8830
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How sleep deprivation affects cognition remains elusive. In our study, we conducted synaptome mapping of excitatory synapses in 125 regions of the mouse brain and found that sleep deprivation selectively reduces synapse diversity in the cortex and in the CA1 region of the hippocampus. Sleep deprivation targeted specific types and subtypes of excitatory synapses while maintaining total synapse density (synapse number/area). Synapse subtypes with longer protein lifetimes exhibited resilience to sleep deprivation, similar to observations in aging and genetic perturbations. Moreover, the altered synaptome architecture affected the responses to neural oscillations, suggesting that sleep plays a vital role in preserving cognitive function by maintaining the brain's synaptome architecture. https://doi.org/10.7488/ds/7779
提供机构：
University of Edinburgh. Centre for Clinical Brain Sciences
创建时间：
2024-07-25
