Applications of C–H Functionalization Logic to Cyclobutane Synthesis

The
application of C–H functionalization logic to target-oriented
synthesis provides an exciting new venue for the development of new
and useful strategies in organic chemistry. In this article, C–H
functionalization reactions are explored as an alternative approach
to access pseudodimeric cyclobutane natural products, such as the
dictazole and the piperarborenine families. The use of these strategies
in a variety of complex settings highlights the subtle geometric,
steric, and electronic effects at play in the auxiliary guided C–H
functionalization of cyclobutanes.

C-H官能团化逻辑在目标导向合成中的应用，为有机化学中新策略的开发与构建提供了激动人心的全新领域。本文中，C-H官能团化反应被探索作为一种获取类伪二聚体环丁烷天然产物（如二唑和胡椒阿洛内因家族）的替代途径。这些策略在复杂环境中的运用，凸显了辅助引导下环丁烷C-H官能团化过程中所涉及的微妙几何、立体和电子效应。