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Crystal structure of Compound 19 bound to IRAK4

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Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
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Crystal structure of Compound 19 bound to IRAK4 Descriptor: Interleukin-1 receptor-associated kinase 4, N-{2-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, SULFATE ION Authors: Kiefer, J.R, Bryan, M.C, Lupardus, P.J, Zarrin, A.A, Rajapaksa, N.S, Gobbi, A, Drobnick, J, Kolesnikov, A, Liang, J, Do, S. Deposit date: 2019-11-12 Release date: 2019-11-20 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. Acs Med.Chem.Lett., 11, 2020
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2019-11-12
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