Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
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Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.
创建时间：
2017-03-08
