Total daily energy expenditure (TDEE; kcal/day) measured by doubly labeled water at M0, M3 and M6.

Predicted values were calculated on the basis of the equations generated at baseline. A significant P value indicates ��metabolic adaptation��, i.e. the measured value is below the predicted value for the new metabolic mass (fat-free mass and fat mass). Data are mean��SE for the 46 participants who completed the study.*indicates a significant change from baseline.