Chemoproteomic Cysteine Selectivity of VVD-446 and VVD-860
收藏NIAID Data Ecosystem2026-05-10 收录
官方服务:
资源简介:
Global assessment of cysteine selectivity for VVD compounds that covalently engage KEAP1 C151
应用场景:
创建时间:
2025-12-10
相关数据集
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
IDH1 plays a critical role in a number of metabolic processes and serves as a key source of cytosolic NADPH under conditions of cellular stress. However, few inhibitors of wild-type IDH1 have been rep
NIAID Data Ecosystem90
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S N Ar Electrophiles
Fibroblast growth factor receptor 4 (FGFR4) is thought to be a driver in several cancer types, most notably in hepatocellular carcinoma. One way to achieve high potency and isoform selectivity for FGF
NIAID Data Ecosystem90
Specific covalent inhibitor (5) of ERK2
Specific covalent inhibitor (5) of ERK2 Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Mitogen-activated protein kinase 1, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-2
Protein Data Bank Japan2024-10-09 更新50
Cov_FB3D: A De Novo Covalent Drug Design Protocol Integrating the BA-SAMP Strategy and Machine-Learning-Based Synthetic Tractability Evaluation
De novo drug design actively seeks to use sets of chemical rules for the fast and efficient identification of structurally new chemotypes with the desired set of biological properties. Fragment-based
NIAID Data Ecosystem90
Covalent bond formation of synthetic ligand with hPPARg-LBD
Covalent bond formation of synthetic ligand with hPPARg-LBD Descriptor: 2-[E-(E-2-oxidanylidenehexadec-5-enylidene)amino]ethanoic acid, Peroxisome proliferator-activated receptor gamma Authors: Kojima
Protein Data Bank Japan2024-11-06 更新70



