Multiple linear regression analysis between GM and behavior, cytokines, and BDNF.

Several significant associations are seen between GM and both behavior and systemically circulating inflammatory mediators, indicating a possible influence from the gut on the immune system and the brain. Furthermore a certain GM composition seems to be associated with both improved memory and increased levels of BDNF in mice not subjected to any of the experimental diets. The PCoA analysis denotes whether data was weighted (W) or not (UW) by bacterial abundance and the principal component (PC) listed denotes the significant factor(s) in the multiple linear regression models. Not shown and non-significant are: Risk assessment on OA, Time spent in OF center and PFC BDNF. GM was not correlated to IL-1β, IL-10 and TNF-α, as all samples were at basal concentrations regarding these cytokines. Italic: negative correlation. Bold: Positive correlation.