SNPs associated with <i>ptxA1</i>, <i>prn2/3</i> and <i>ptxP3</i>.

(a)SNP no corresponds to numbers in row 2 of Supplementary table S4: Annotation of SNPs. More information about the SNP can be found in this table. (b)Subcellular localization was predicted for proteins were no localization was determined experimentally using PSORTb vs 3.0 (http://www.psort.org/psortb/). Cyt: cytoplasm, im: inner membrane, per: periplasm, om: outer membrane, es: extracellular space, uk: unknown, -: not determined. (c)Information of regulation by bvg was retrieved from Cummings et al. [56], Streefland et al. [78] and de Gouw et al. in preparation. Act: bvg-activated, rep: bvg-repressed. (d)Information about domains, active sites and conserved positions was derived from SMART (http://smart.embl-heidelberg.de) and Conserved Domain Database (http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml).