Additional file 2: Table S1. of Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

Validation of the data point imputation. Using the publically available transcriptome datasets for 3D7, Dd2 and HB3 from (Llinas et al. NAR 2007), we validated whether the density of the data in our time series (of eight points, at a 6-hour resolution) was sufficient to impute data to a 7.5Â min resolution. For each strain, we selected eight time points evenly spread (6-hrs apart) from which we generated an imputed curve of 384 points. Using Pearson correlation values for gene expression, we then compared each actual hourly time point to the imputed curve to identify the closest matching time point. The imputed percentage column shows where the match occurred in the time series. Actual time points from the original time courses match imputed time points that are fairly evenly spread along the imputation-derived curve. (XLSX 37 kb)