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Genome-wide screen unveils the synthetic lethality targets of mitomycin C

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE132431
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To dig out the synthetic lethality targets of mitomycin C, we we performed Genome-scale CRISPR-Cas9 knockout screening in SNU-1 with 0.1% DMSO or 0.3 µM MMC for 14 days. We found that BRCA2 is a synthetic lethality target of mitomycin C. GeCKO Library screen in SNU-1 with vehicle or MMC for 14 days.
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2022-06-08
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