Induction of transient and adaptive vs maladaptive unfolded protein responses of the endoplasmic reticulum in pancreatic beta cells. Induction of transient and adaptive vs maladaptive unfolded protein responses of the endoplasmic reticulum in pancreatic beta cells

Whole RNA-sequencing of MIN6 cell samples from a drug-treatment time course to investigate how hypersecretion vs. ER calcium disruption influence stress and function adaptation. Overall design: Three independent experiments were peformed in MIN6 beta cells. Each experiment contained 13 samples: A 0h baseline and 1,2,6,24 h for DMSO (0.1%), SW016789 (5uM), and thapsigargin (100nM) as an ER stress control treatment. RNA was collected from all samples at the end of the time course.