pI<sub>50</sub> and IC<sub>50</sub> values for ibuprofen, flurbiprofen and their metabolites towards the inhibition of 0.5 µM [<sup>3</sup>H]AEA hydrolysis by rat brain FAAH.
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Values were determined using the log(inhibitor) vs. response – variable slope (four parameters) algorithm in the Prism 6 computer programe, with top and bottom values constrained to 100% and 0%, respectively. In all cases, Akaike’s informative criteria indicated that the curves were better fitted to these constraints than the equivalent algorithm where the bottom value was not constrained.
创建时间：
2014-07-25
