Phantom FDA

<p>As part of a more general effort to probe the interrelated factors impacting the accuracy and precision of lung nodule size estimation, we have been conducting phantom CT studies with an anthropomorphic thoracic phantom containing a vasculature insert on which synthetic nodules were inserted or attached.</p><p>The utilization of synthetic nodules with known truth regarding size and location allows for bias and variance analysis, enabled by the acquisition of repeat CT scans.  Using a factorial approach to probe imaging parameters (acquisition and reconstruction) and nodule characteristics (size, density, shape, location), ten repeat scans have been collected for each protocol and nodule layout.  The resulting database of CT scans is incrementally becoming available to the public via <em>The Cancer Imaging Archive</em> (TCIA) to facilitate the assessment of lung nodule size estimation methodologies and the development of image analysis software among other possible applications. </p>

作为对影响肺结节大小估计准确性和精度的相关因素进行深入探究的一般性努力的一部分，我们已开展了使用含有血管插入件的拟人化胸部模型进行的伪影CT研究，在该模型上插入了或附着了合成结节。利用具有已知尺寸和位置的合成结节，通过重复CT扫描的获取，实现了偏差和方差分析。采用因子分析法对成像参数（采集和重建）以及结节特征（大小、密度、形状、位置）进行探究，为每个方案和结节布局收集了十次重复扫描。由此产生的CT扫描数据库正逐步通过《癌症影像档案》（TCIA）向公众开放，以促进肺结节大小估计方法的评估以及图像分析软件的开发等潜在应用。