Crystal structure of a CDK6/Vcyclin complex with inhibitor bound
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Crystal structure of a CDK6/Vcyclin complex with inhibitor bound Descriptor: 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine, Cyclin homolog, Cyclin-dependent kinase 6 Authors: Piper, D.E, Walker, N, Wang, Z. Deposit date: 2014-06-20 Release date: 2014-08-06 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. J.Med.Chem., 57, 2014
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2014-06-20
