Top 5 canonical pathways (WT v.s. KO after 24 h fasting).

Figshare2015-12-02 更新2026-04-29 收录

基因敲除通路分析

肝脏代谢调控

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https://figshare.com/articles/dataset/_Top_5_canonical_pathways_WT_v_s_KO_after_24_h_fasting_/1280435 数据链接链接失效反馈

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IPA suggested these pathways are significantly altered by CCRP KO in male mouse liver (ANOVA, pTop 5 canonical pathways (WT v.s. KO after 24 h fasting).

创建时间：

2015-12-02

DOM FIGURE 5 Gene expression of Prkaa1 and Prkaa2 is increased by substrate challenge in hepatocytes from vehicle treated mice ex vivo and by chronic treatment with AZD1656 (3mg/kg) for 8 wk.

AMPK信号通路

肝脏代谢调控

mRNA levels for Prkaa1 (AMPK-alpha1) and Prkaa2 (AMPK-alpha2) were determined in the experiments described in Fig. 4 in hepatocytes isolated from mice treated for 8-weeks with vehicle or AZD1656 (1 or

DataCite Commons2020-06-25 更新80

Liver X receptor controls a bifurcated transcriptional program where lipogenesis genes overshoot upon refeeding while cholesterol biosynthesis genes return to pre-fasting levels [lxr_chip]

肝脏代谢调控

转录因子功能分析

Transitions from a fed to a fasted state are common in mammals. The liver orchestrates adaptive responses to feeding/fasting by transcriptionally regulating metabolic pathways of energy usage and stor

NIAID Data Ecosystem20

Liver transcriptome analysis of lean mice expressing a SUMO-deficient Prox1 (K556R) mutant in hepatocytes. Liver transcriptome analysis of lean mice expressing a SUMO-deficient Prox1 (K556R) mutant in hepatocytes

肝脏代谢调控

转录组学分析

Accumulation of excess nutrients hampers proper liver function and is linked to non-alcoholic fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation of hep

NIAID Data Ecosystem10

Transcription profiling by array of liver tissues from mice with liver-specific knockout of Pit1 and wild-type littermates fed with either a high-fat diet or chow control diet

肝脏代谢调控

胰岛素信号通路

The liver plays a central role in whole-body lipid and glucose homeostasis. Increasing dietary fat intake results in increased hepatic fat deposition, which is associated with a risk for development o

Alliance of Genome Resources20

Phosphoproteomics-directed manipulation reveals SEC22B as an hepatocellular signaling node governing metabolic actions of glucagon

肝脏代谢调控

胰岛素信号通路

The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmocotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little of ho

NIAID Data Ecosystem10

Top 5 canonical pathways (WT v.s. KO after 24 h fasting).

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