Pikfyve Inhibitor
收藏Figshare2025-08-13 更新2026-04-28 收录
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资源简介：
In Silico Discovery and Experimental Validation of Natural Derivatives as Inhibitor of Phosphoinositide Kinase, Pikfyve A library of over 3,500 NPs was screened against the PIKfyve structure (PDB: 7K2V) using Glide XP docking, followed by MM-GBSA binding free energy estimation and ADMET profiling with SwissADME and pkCSM. Among the top docked candidates, Trilobatin demonstrated favourable pharmacokinetic properties, compliance with drug-likeness criteria, and acceptable safety profile.
创建时间：
2025-08-13
