Next-Generation Sequencing of COLO-829 Tumour/Normal Melanoma Cell Line Pair

This collection contains next-generation sequencing BAM files from the COLO-829 tumour/normal melanoma cell line pair sequenced using 3 platforms – (1) Illumina HiSeq whole genome; (2) Life Technologies SOLiD whole genome; (3) Life Technologies SOLiD exome sequencing using the Agilent SureSelect 50 Mbase enrichment kit.

This dataset provides a high coverage reference set of sequences that can be used to examine the performance of somatic variant calling algorithms in cancer. The dataset allows comparison of two different sequencing platforms (SOLiD and HiSeq) as well as an examination of the sensitivity and specificity effects of sequencing exomes as compared with genomes.