Structure of GluN1b-GluN2D NMDA receptor in complex with competitive antagonist R-CPP and allosteric inhibitor YY-23

Structure of GluN1b-GluN2D NMDA receptor in complex with competitive antagonist R-CPP and allosteric inhibitor YY-23 Descriptor: (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[(2~{S})-2-methyl-4-[(1~{R},2~{R},4~{S},6~{S},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S},18~{R})-7,9,13,18-tetramethyl-16-oxidanyl-5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan-6-yl]butoxy]oxane-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... Authors: Zhang, J.L, Zhu, S.J, Guo, F. Deposit date: 2024-01-25 Release date: 2025-01-22 Last modified: 2026-02-04 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons. Sci Adv, 11, 2025