Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage.
收藏PubMed Central1996-07-09 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC38947/
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资源简介：
We have used telomeric DNA to break two acrocentric derivatives of the human Y chromosome into mini-chromosomes that are small enough to be size- fractionated by pulsed-field gel electrophoresis. One of the mini-chromosomes is about 7 Mb in size and sequence-tagged site analysis of this molecule suggests that it corresponds to a simple truncation of the short arm of the Y chromosome. Five of the mini-chromosomes are derived from the long arm, are all rearranged by more than a simple truncation, and range in size from 4.0 Mb to 9 Mb. We have studied the mitotic stabilities of these mini-chromosomes and shown that they are stably maintained by cells proliferating in culture for about 100 cell divisions. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-07-09
