scRNA seq analysis of adult CD34+ cells ex vivo cultured with Delta1ext-IgG under normoxia or hypoxia

We demonstrate that ex vivo culture of human adult hematopoietic stem and progenitor cells with Delta1ext-IgG under hypoxia limits endoplasmic reticulum stress in long-term repopulating hematopoietic stem cells and, to a lesser extent, in lineage committed progenitors compared to normoxic cultures. Data were submitted on behalf of Dr. Larochelle's lab at the NIH. Overall design: RNA-seq of G-CSF mobilized CD34+ cells ex vivo cultured with Delta1ext-IgG under normoxia or hypoxia