Supplementary data 1. Significant eQTL-gene contacts identified within LGRN, Ensembl gene annotations, and LOEUF analysis results

The liver gene regulatory network (LGRN) we constructed consisted of 327,145 eQTLs and 8097 genes with 468,560 distinct spatially constrained eQTL-target gene interactions. The majority of the eQTLs (92% with single target genes, and 95% with multiple target genes) acted via cis regulatory interactions. Within the LGRN, 77% of the eQTL target genes are protein coding. Moreover, the genes that were targeted by trans-eQTLs are more likely to be intolerant to loss-of-function mutations.

我们所构建的肝脏基因调控网络（LGRN）由327,145个表达量定量性状位点（eQTLs）和8,097个基因组成，其中包含468,560个独特的空间限制性eQTL-靶基因相互作用。绝大多数的eQTLs（其中92%具有单一靶基因，95%具有多个靶基因）通过顺式调控相互作用发挥作用。在LGRN中，77%的eQTL靶基因编码蛋白质。此外，被顺式eQTLs靶向的基因更有可能对功能丧失突变表现出不耐受性。