Sequences of ASOs used in the study.

All RNase H-dependent ASOs used for target mRNA reduction were 20 bases in length, all linkages were phosphorothioate and 2′-O-methoxyethyl residues were incorporated at the positions 1–5 and 16–20. An analog of each ASO was also synthesized with 2′-O-methoxyethyl at each position.*Asterisks indicate ASOs targeting SOD/TO-AB mutant sites and base changes relative to parent ASO are indicated by lower case letters.Sequences of ASOs used in the study.