Relationships between baseline CSF BDNF concentration with cross-sectional and longitudinal cognitive performance.

Data are: linear regression model coefficient (SE) per10 pg/ml; p-value. Models 1, 2, and 3: Cross-sectional relationships between baseline CSF BDNF concentration and coincident cognitive test scores in 121 Normals with baseline neuropsychological testing. Model 1: adjusted for age, gender, and years of education. Model 2: Model 1 plus CSF Aβ42 and total tau concentrations. Model 3: Model 2 plus APOE ε4 (ε4− vs. ε4+) and Met-BDNF genotype (G/G vs. G/A or A/A) (n = 119 because of two missing values for rs6265 genotype). Models 4, 5 and 6: longitudinal relationships between baseline CSF BDNF concentration and subsequent annual change in cognitive test scores for 50 Normals with follow-up evaluation. Model 4: adjusted for age, gender, years of education, and baseline test score. Model 5: Model 4 plus baseline CSF Aβ42 and total tau concentrations. Model 6: Model 5 plus APOE ε4 (ε4− vs. ε4+) and Met-BDNF genotype (G/G vs. G/A or A/A).