Consequences of decreased TNAP activity during osteogenic differentiation of periodontal ligament cells – a new model for dental defects in hypophosphatasia

The effects of TNAP inhibition with levamisole during osteogenic differentiation were analyzed in primary human periodontal ligament cells since patients suffering from hypophosphatasia often display dental symptoms. Overall design: Analysis of the influence of TNAP inhibition via levamisole in dental stem cells isolated from the periodontal ligament during osteogenic differentiation