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Large-scale discovery of potent, compact and lineage specific enhancers for gene therapy vectors

NIAID Data Ecosystem2026-05-02 收录

基因治疗载体

增强子筛选优化

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252163 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-05-22

腺相关病毒载体

基因治疗载体

AAV8 human HEK293-produced, empty capsid Descriptor: Capsid protein Authors: Paulk, N.K, Poweleit, N. Deposit date: 2019-08-18 Release date: 2020-06-03 Last modified: 2024-03-20 Method: ELECTRON MICRO

Protein Data Bank Japan2024-03-20 更新40

Fab1-4 in complex with the capsid of Adeno-associated virus type 9

病毒衣壳-抗体复合物结构

基因治疗载体

Fab1-4 in complex with the capsid of Adeno-associated virus type 9 Descriptor: Capsid protein VP1, Fab1-4 heavy chain, Fab1-4 light chain Authors: Mietzsch, M, McKenna, R. Deposit date: 2024-03-25 Rel

Protein Data Bank Japan2025-06-11 更新20

Engineered VPg saRNA achieves cap-independent, low-immunogenic and precise encoding of therapeutic proteins in vivo.

蛋白质尿苷酰化检测

基因治疗载体

HPLC-MS analysis of nucleosidylated VPg was performed on a total of 2 samples, including unmodified VPg (n=1) and nucleosidylated VPg (n=1) species with 3 technical replicates. Samples were prepared b

Figshare2025-12-04 更新10

A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal

腺病毒载体

基因治疗载体

Adenoviruses are attractive vectors for the delivery of foreign genes into mammalian cells for gene therapy. However, current vectors retain many viral genes that, when expressed at low levels, contri

PubMed Central1996-11-26 更新40

Integrating Adenovirus–Adeno-Associated Virus Hybrid Vectors Devoid of All Viral Genes

基因治疗载体

病毒载体工程

Recently, we demonstrated that inverted repeat sequences inserted into first-generation adenovirus (Ad) vector genomes mediate precise genomic rearrangements resulting in vector genomes devoid of all

PubMed Central20

Large-scale discovery of potent, compact and lineage specific enhancers for gene therapy vectors

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