UniProt Knowledgebase

The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. In addition to capturing the core data mandatory for each UniProtKB entry (mainly, the amino acid sequence, protein name or description, taxonomic data and citation information), as much annotation information as possible is added. This includes widely accepted biological ontologies, classifications and cross-references, and clear indications of the quality of annotation in the form of evidence attribution of experimental and computational data. The UniProt Knowledgebase consists of two sections: a reviewed section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis (aka "UniProtKB/Swiss-Prot"), and an unreviewed section with computationally analyzed records that await full manual annotation (aka "UniProtKB/TrEMBL").通用蛋白质知识库（UniProt Knowledgebase，UniProtKB）是收集蛋白质功能信息的核心枢纽，其注释兼具准确性、一致性与丰富性。该库不仅收录每条UniProtKB条目必需的核心数据——主要包括氨基酸序列、蛋白质名称或描述、分类学数据及引用信息——还会尽可能补充各类注释内容，涵盖广泛认可的生物本体论、分类体系与交叉引用，并通过实验与计算数据的证据标注方式，清晰体现注释的质量层级。通用蛋白质知识库包含两个子库：一是已评审子库，收录经人工注释的条目，其信息来自文献提取与编目员评估后的计算分析（即UniProtKB/Swiss-Prot）；二是未评审子库，收录经计算分析但尚未完成全部人工注释的条目（即UniProtKB/TrEMBL）。

搜集汇总

背景与挑战

背景概述

UniProt Knowledgebase (UniProtKB) 是蛋白质功能信息的核心资源库，提供高质量、全面的蛋白质序列和注释数据。它包含经过人工审阅的UniProtKB/Swiss-Prot和未经审阅的UniProtKB/TrEMBL两部分，涵盖氨基酸序列、分类学信息及丰富的功能注释。该数据库支持多种分析工具，并整合了来自基因组和公开数据库的蛋白质数据集。