Genetic deletion of translocator protein exacerbates post-sepsis syndrome with activation of the C1q pathway in septic mouse model

To investigate the role of TSPO in the sequelae of sepsis induced by cecal ligation and puncture (CLP), hippocampal gene expression changes after CLP surgery were examined in wild-type and TSPO KO mice Animals were divided into three groups (i) Wiley type (WT) + sham, (ii) WT + CLP, and (iii) TSPO knockout + CLP, and hippocampal gene expression was examined on day 17 for each group