Figure S1 - A Conserved Mammalian Protein Interaction Network

Distributions of Pearson’s and Spearman’s Rank Sums correlation coefficients of the true PPIs and pseudo random PPIs respectively. The true (solid lines) and pseudo random (dashed lines) PPIs. A) Distribution of the Pearson’s correlation coefficient r includes a ‘bump’ at approximately r = 0.7, indicating that the data are non-normally distributed. This is caused by branches that are outliers compared to other branches in some of the mirrortrees, which then inflates Pearson’s r. That these correlations are spurious is suggested by the fact that no similar bump is seen in B), the Spearman’s rank sums correlation coefficients ρ for the same data. (EPS)