Additional file 3 of Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

Additional file 3: Table S5. ASPC marker genes from SAT snRNA-seq data of 6 individuals in FTC. Table S8. Seventy-six SAT ASPC genes (i.e. 72 ASPC marker genes and four transcription factor genes regulating ASPC marker genes) are significantly differentially expressed (DE) by age (FDR<0.05) using the ASPC data from the SAT snRNA-seq cohort (n=15). Table S11. The pathway tool WebGestalt identifies significantly (FDR<0.05) overrepresented developmental and differentiation-related Gene Ontology biological processes within the 76 age-DE SAT ASPC genes. Table S12. The pathway tool WebGestalt identifies significantly (FDR<0.05) overrepresented Gene Ontology biological processes within the 79 non-age-DE SAT ASPC genes. Table S13. Significant correlations (FDR<0.05) between the expression of the 76 age-DE SAT ASPC genes and cardiometabolic phenotypes using subcutaneous adipose bulk RNA-seq data from METSIM (n=335). Table S14. Significant correlations (FDR<0.05) between the expression of the 79 non-age-DE SAT ASPC marker genes and cardiometabolic phenotypes using subcutaneous adipose bulk RNA-seq data from METSIM (n=335). Table S15. Nearly half (47.4%) of the 76 age-DE SAT ASPC genes show significant DE by age (FDR<0.05 in the same direction as in the SAT snRNA-seq cohort) in VAT ASPCs from a publicly available VAT snRNA-seq data of 10 individuals. Table S16. The pathway tool WebGestalt identifies significantly (FDR<0.05) overrepresented Gene Ontology (GO) biological processes within the 36 age-DE ASPC marker genes with consistent DE across ASPCs from the SAT and VAT fat depots. Table S17. Seventy-five of the 76 age-DE SAT ASPC genes are all DE across the 6 measured timepoints during a 14-day SAT ASPC differentiation (i.e. adipogenesis) experiment. Table S18. Clustering of the age-DE SAT ASPC genes by their expression profiles during a 14-day SAT ASPC differentiation (i.e. adipogenesis) experiment.