White blood cell counts and differentials before and 4 hours after intravenous endotoxin administration in healthy subjects pretreated with etanercept or placebo.

Sixteen healthy males received an intravenous injection with endotoxin (1 ng/kg) at t = 0. Subjects were pretreated (−48 hours) with etanercept (50 mg, n = 8) or placebo (n = 8). White blood cell counts (WBC) and differentials were determined directly before and 4 hours after endotoxin injection. ***p<0.001; paired student t test of placebo-treated baseline and endotoxin infusion groups. ##p<0.01, ###p<0.001; paired student t test of etanercept-treated baseline and endotoxin infusion groups. There were no differences between etanercept and placebo treated subjects at either t = 0 or t = 4 hours.