Reduced lipolysis is a common lipid accumulation mechanism for different subtypes of lipomas
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https://www.ncbi.nlm.nih.gov/sra/SRP233282
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We used RNA-seq to inquire gene expression profiles of lipomas with HMGA2-fusions and without gene fusions. We demonstrate that HMGA2-fusions lipomas are a specific subtype and that the common shared lipid accumulation mechanism is a reduction in lipolysis, with most gene-dysregulations leading to a reduced cAMP in the adipocyte. Overall design: Characterization of lipomas and matched subcutaneous adipose tissue (SAT)
创建时间:
2020-05-26



