Lactoferrin fusion protein and method for producing same

An object of the present invention is to provide a lactoferrin fusion protein and a method for producing the same， which maintains the biological activity of natural lactoferrin， has a significantly extended lifespan in the body， and has clinical utility superior to that of natural lactoferrin and recombinant lactoferrin. The present invention is a fusion protein of a protein or peptide containing an FcRn binding region and a bioactive fragment or peptide of lactoferrin or lactoferrin， (Wherein， LF is lactoferrin or a bioactive fragment or peptide of lactoferrin， Y is a protein or peptide containing an FcRn binding region， s is a sequence of 0-10 arbitrary amino acids， and n represents an integer of 1-10) The indicated fusion protein or a variant thereof is provided. The purpose of the invention is to provide: a lactoferrin fusion protein that retains the bioactivity of natural lactoferrin， significantly prolongs the in vivo lifespan， and has better clinical utility than natural lactoferrin and recombinant lactoferrin; and a method for producing the same. The invention provides a fusion protein of: a protein or peptide containing an FcRn binding region; and lactoferrin or a lactoferrin bioactive fragment or peptide; wherein the fusion protein is represented by (LF-s-Y)n or (Y-s-LF)n (in the formula， LF represents lactoferrin or a lactoferrin bioactive fragment or peptide; Y represents a protein or peptide containing an FcRn binding region; s represents a sequence of any 0-10 amino acids; and n represents an integer of 1-10)， or a variant thereof. The purpose of the invention is to provide: a lactoferrin fusion protein that retains the bioactivity of natural lactoferrin， significantly prolongs the in vivo lifespan， and has better clinical utility than natural lactoferrin and recombinant lactoferrin; and a method for producing the same. The invention provides a fusion protein of: a protein or peptide containing an FcRn binding region; and lactoferrin or a lactoferrin bioactive fragment or peptide; wherein the fusion protein is represented by (LF-s-Y)n or (Y-s-LF)n (in the formula， LF represents lactoferrin or a lactoferrin bioactive fragment or peptide; Y represents a protein or peptide containing an FcRn binding region; s represents a sequence of any 0-10 amino acids; and n represents an integer of 1-10)， or a variant thereof.