Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older

The Cardiovascular Health Study (CHS) is a prospective study of risk factors for development and progression of CHD and stroke in people aged 65 years and older. The 5,888 study participants were recruited from four U.S. communities and have undergone extensive clinic examinations for evaluation of markers of subclinical cardiovascular disease. The original cohort, enrolled in 1989-90, totaled 5,201 participants. A supplemental cohort of 687 predominantly African-American participants was enrolled in 1992-93.

Clinic examinations were performed at study baseline and at annual visits through 1998-1999, and again in 2005-2006. Examination components included medical and personal history, medication inventory, ECG, blood pressure, anthropometry, assessment of physical and cognitive function, and depression screening. Other components done less frequently included phlebotomy, spirometry, echocardiography, carotid ultrasound, cerebral magnetic resonance imaging, measurement of ankle-brachial index and retinal exam. Participants were contacted by telephone annually between exams to collect information about hospitalizations and potential cardiovascular events. Since 1999, participants have been contacted every six months by phone, primarily to identify cardiovascular events and to assess physical and cognitive health.

Standard protocols for the identification and adjudication of events were implemented during follow-up. The adjudicated events are myocardial infarction, angina, heart failure (HF), stroke, transient ischemic attack (TIA), claudication and mortality.

The Cardiovascular Health Study Cohort is utilized in the following dbGaP substudies. To view genotypes, analysis, expression data, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" section of this top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort: an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older.

心血管健康研究（Cardiovascular Health Study, CHS）是一项针对65岁及以上人群冠心病（Coronary Heart Disease, CHD）与脑卒中发生及进展危险因素的前瞻性队列研究。本研究共纳入5888名研究对象，招募自美国4个社区，所有受试者均接受了全面的临床检查，以评估亚临床心血管疾病标志物水平。研究初始队列于1989-1990年纳入，共计5201名受试者；1992-1993年新增补充队列，纳入687名以非裔美国人为主的受试者。

临床检查在研究基线时开展，之后每年随访一次直至1998-1999年，并于2005-2006年再次进行检查。检查项目涵盖病史与个人史采集、药物清单记录、心电图（Electrocardiogram, ECG）、血压测量、人体测量、躯体与认知功能评估以及抑郁筛查。开展频率较低的检查项目则包括静脉采血、肺量测定法、超声心动图、颈动脉超声、颅脑磁共振成像、踝臂指数测量以及眼底检查。两次检查之间，研究人员会通过电话每年随访一次，以收集受试者的住院情况与潜在心血管事件相关信息。自1999年起，随访频率调整为每半年一次电话随访，主要用于确认心血管事件发生情况，并评估受试者的躯体与认知健康状态。

随访期间，研究采用标准化方案开展事件识别与裁定工作。经裁定确认的事件包括心肌梗死、心绞痛、心力衰竭（Heart Failure, HF）、脑卒中、短暂性脑缺血发作（Transient Ischemic Attack, TIA）、间歇性跛行以及全因死亡。

心血管健康研究队列被应用于以下dbGaP（Database of Genotypes and Phenotypes, dbGaP）子研究中。若需查看这些子研究中收集的基因型数据、分析结果、表达谱数据、其他分子数据以及衍生变量，请点击下方或本顶级研究页面“子研究(Substudies)”板块中的相关子研究：phs000287 心血管健康研究（CHS）队列：一项由美国国立心肺血液研究所（National Heart, Lung, and Blood Institute, NHLBI）资助的、针对65岁及以上成人心血管疾病危险因素的观察性研究。