ATF4 regulates MYB to increase g-globin in response to loss of β-globin

NIAID Data Ecosystem2026-03-12 收录

血红蛋白转换疗法

珠蛋白基因调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE153768 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2020-10-26

The Aγ-globin 3′ element provides no unique function(s) for human β-globin locus gene regulation

珠蛋白基因调控

顺式调控元件功能

The human β-globin locus is activated transcriptionally by a complex series of events that culminate in appropriate temporal and tissue-specific control over five separate genes during embryonic and e

PubMed Central1998-08-18 更新40

Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci

珠蛋白基因调控

CTCF绝缘子元件

A binding site for the transcription factor CTCF is responsible for enhancer-blocking activity in a variety of vertebrate insulators, including the insulators at the 5′ and 3′ chromatin boundaries of

PubMed Central30

Reactivation of Zeta-Globin by deletion of BCL11A and LRF in murine cells

血红蛋白病基因治疗

珠蛋白基因调控

The alpha and beta-globin loci harbour genes that are expressed during development and silenced throughout post-natal life. Learning to reactivate these genes may offer new therapeutic approaches for

NIAID Data Ecosystem20

Reactivation of Zeta-Globin by deletion of BCL11A and LRF in murine cells. Reactivation of Zeta-Globin by deletion of BCL11A and LRF in murine cells

血红蛋白病基因治疗

珠蛋白基因调控

The alpha and beta-globin loci harbour genes that are expressed during development and silenced throughout post-natal life. Learning to reactivate these genes may offer new therapeutic approaches for

NIAID Data Ecosystem40

Mechanism of DNase I hypersensitive site formation within the human globin locus control region.

珠蛋白基因调控

染色质超敏感位点

The human beta-like globin gene locus contains embryonic, fetal, and adult globin genes that are regulated in a developmentally timed, as well as a tissue-specific, manner. The locus control region (L

PubMed Central1992-02-01 更新20

ATF4 regulates MYB to increase g-globin in response to loss of β-globin

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