Data on study titled: Effects of Butterfly Pea Flower (Clitoria ternatea) Extract Shampoo as anti inflammation in dandruff scalp: Real time PCR Quantitative Test for Interleukin-8

<b>Background</b>Dandruff is characterized by flaking, redness, and itching of the scalp, negatively impacting quality of life. The pathogenesis of dandruff involves inflammatory processes, but remains not fully understood. Clitoria ternatea, known for its anti-inflammatory and antioxidant properties, presents potential as a dandruff treatment. This study aims to evaluate the anti-inflammatory effects of butterfly pea flower extract (Clitoria ternatea) shampoo on dandruff, specifically its impact on the Quantification cycle (Cq) of mRNA IL-8. <b>Methods</b>In a pre-experimental study, 70 dandruff patients were treated with either 20% Clitoria ternatea extract shampoo or 2% ketoconazole shampoo. Quantitative RT-PCR was used to assess the Cq of mRNA IL-8 at baseline and after four weeks of treatment.<b>Results </b>The mean IL-8 mRNA Cq before using Clitoria ternatea shampoo was 29.55, which increased to 33.02 after four weeks (p &lt; 0.001), indicating lower mRNA expression. Similarly, the mean IL-8 mRNA Cq before using ketoconazole shampoo was 29.96, which increased to 34.00 after four weeks (p &lt; 0.001). There was no significant difference between the two groups (p = 0.459).<b>Conclusion</b>The anti-inflammatory effects of Clitoria ternatea, as evidenced by the reduction in IL-8 mRNA expression, suggest that its active ingredients may influence the pathogenesis of dandruff, offering a potential therapeutic option for managing this condition.