Csk and FAK protein tyrosine kinase phylogenies

(A) and (B) Best of 50 ML trees as inferred by RAxML under the LG+ Γ model (see STAR methods). Purple, pink, orange, blue, light blue and brown texts indicate C. owczarzaki, M. vibrans, Pigoraptor (strains Opistho-1 and Opistho-2), S. multiformis (strain Colp-12), C. limacisporum and H. sapiens, respectively. The query sequence is indicated in red. A shaded rectangle indicates the protein in question in filastereans and Pluriformea, if present. An asterisk indicates human proteins annotated as Csk (A) and FAK (B), respectively. Other protein tyrosine kinases are indicated and were identified by the annotated C. owczarzaki homolog(s) present in the respective clade if not otherwise indicated. Clades in (B) are collapsed to increase clarity. Node supports are nonparametric ML bootstrap values obtained from 1000 ML replicates using the LG+ Γ model implemented in RAxML, numbers at nodes represent bootstrap supports of greater than 50%. The scale bar represents the estimated number
of amino acid substitutions per site.