Effect of genotype grouping of Pfmdr1 on EC50 for chloroquine, mefloquine, lumefantrine and artesunate using nonlinear mixed-effects modelling.

95% confidence intervals in brackets; †Reference group; #Emax fixed to 0.98; ?E0 fixed to 0.01.Between−isolate variance estimate (standard errors) for EC50: − 0.39(0.026) chloroquine, 0.56(0.043) mefloquine, 0.63(0.050) lumefantrine, 0.67(0.048) artesunate.Within-isolate variance estimates (standard errors) are:-.proportional – 0.013(0.0018) chloroquine, 0.010(0.0011) mefloquine, 0.019(0.0020) lumefantrine, 0.025(0.0037) artesunate;additive – 0.001(0.0002) chloroquine, 0.001(0.0001) mefloquine, 0.0009(0.0002) lumefantrine, 0.0007(0.0002) artesunate.