Characterization of heterogeneity in gastric cancer cells derived from independent lineages at single-cell resolution

Analysis of genomic and transcriptomic profiling has proposed new insights for diagnosis and prognosis in gastric cancer (GC). Human GCs are a unified model composed of diverse cells, including premalignant, immune and cancer. In this study, we present a human cell population of GC and premalignant states at single cell resolution using the 10X Chromium platform. We profiled 112,041 gastric cell landscape across 24 individuals with adjacent normal and GC lesions. For a total of 24 patients with 9 intestinal gastric cancers (IGC) and 15 diffuse gastric cancers (DGC), 13,022 cells consisted of 47 biopsies both 24 GC lesions and 23 adjacent normals were selected after a quality control.